"Top 3" because these are the most frequent. The rest in list 4 is just as frustrating though.
Mass Effect 2 (v 1.01) suffers 3 horrible bugs:
- Sudden airlift of Shepard (squad follows) with no escape. Under attack this makes Shepard an easy target, dead. Also stuck between crates with no way out. Only solution: reload savegame.
- Cover standup: during crossfire, Shepard when ducking for cover often stands up again! so you have to duck twice! The frequency differs per situation, at some places it never happens, sometimes it is 1 out of 10 but may also happen 9 out of 10 times. Under fire, when Shepard's health is almost lost > quickly duck > she stands up
> quickly duck again. Often she dies by standing up and receiving a fatal rocketblast right in the face.
- Custom Female Shepard has no eyelids; only the lashes blink. It's a flaw in the face customization tool. This ruins her (otherwise superbly done) face.
- And a lot more Mass Effect 2 bugs that didn't make top 3, and other flaws
Sudden airlift of Shepard (squad follows) with no escape. Under attack this makes Shepard an easy target, dead. Also stuck between crates with no way out. Only solution: reload savegame.
ALL THESE SUDDEN AIRLIFTS ARE GAME-STOPPING.


It completely ruins that recommended feature "Take cover to regain health" by lifting Shepard up and exposing her to be killed, or at least getting Shepard stuck with no escape except 'Reload (Auto-/Quick-) save'.
Happens completely unsuspected and ruins everything.
- Start of "Horizon".
Next to a tall crate. While taking cover against it and aiming at an enemy, Shepard is suddenly airlifted ontop of the crate, no escape. Easy target. Dead.
"Take cover to regain health"...